The provided code is a computational model aimed at simulating the behavior of a Pyramidal cell, specifically layer 5 (L5) in the prefrontal cortex (PPC), known for its intrinsically bursting properties. These neurons are crucial for various higher cognitive functions, like decision-making and modulation of synaptic inputs, and are characterized by their unique firing patterns and integration of excitatory synaptic inputs.
pcdend1
), representing the proximal and distal dendritic segments. This structure is fundamental in capturing the spatial distribution and integration of synaptic inputs in L5 pyramidal neurons.Sodium (Na+) and Potassium (K+) Channels: The presence of gnatbar_ichan2
, gkfbar_ichan2
, and gksbar_ichan2
parameters simulates the sodium and potassium channel dynamics crucial for the generation of action potentials.
Calcium (Ca2+) Channels: The it
T-type calcium channel is inserted with varying conductance (gcabar_it
), affecting the bursting properties and synaptic integration. Calcium dynamics are significant for synaptic plasticity and signaling within the neuron.
HCN Channels: The hcn1
channel is represented, contributing to the neuron's depolarizing sag and resultant pacemaker potentials. These channels are known to influence the resting membrane potential and synaptic integration.
gskbar_gskch
for calcium block and gnatbar_ichan2
for sodium block allow simulation of pharmacological effects like those of Mibefradil and TTX, respectively, which are known to alter ionic conductance and influence neuronal excitability.IClamp
object is used to inject current into the soma to maintain the cell at approximately -75 mV, imitating experimental slice conditions where the membrane potential is controlled for studying specific ionic currents or synaptic responses.Overall, the code provides a sophisticated tool for studying the biophysical properties of PPC L5 pyramidal cells, focusing on how intrinsic and synaptic properties contribute to their complex firing patterns and potential roles in higher-order brain functions.