The code provided is a model of the leak current in a neuron, which is a fundamental component of ion flow across the neuronal membrane. Here's the biological basis: ### Biological Basis **Leak Current:** Leak currents are passive currents that occur due to the constant, non-gated passage of ions through the neuronal membrane. Unlike gated channels that require specific stimuli to open or close, leak channels are always open and contribute to the resting membrane potential of the neuron. **Membrane Potential and Ion Permeability:** The resting membrane potential is primarily maintained by the differential permeability of the membrane to various ions (mainly sodium, potassium, and chloride) and the non-uniform distribution of these ions across the membrane. The leak current typically involves ions such as potassium (K+) and sodium (Na+), which passively diffuse through these non-gated channels. ### Key Aspects in the Code - **Reversal Potential (Eleak):** The reversal potential (`Eleak = -65 mV`) is the membrane potential at which there is no net flow of the specific ions contributing to the leak current. It reflects the equilibrium potential of the ions and is a major determinant of the resting membrane potential. - **Conductance (gmax):** `gmax (S/cm2)` represents the maximum conductance of the leak channels. It defines the ease with which ions can pass through the channel, affecting how the leak current contributes to changes in membrane potential. - **Current Calculation (i):** The code models the leak current (`i`) as a product of the conductance (`gmax`) and the driving force (`(v-Eleak)`). This reflects the biophysical principle where current is proportional to conductance and the difference between the membrane potential and the equilibrium potential. ### Biological Importance The leak current plays a critical role in stabilizing the resting membrane potential and affecting the excitability of neurons. By allowing a steady-state flow of ions, these currents help maintain the ionic gradients that are crucial for various cellular processes, including action potential generation.