The code provided models various ionic currents in sensory axons, with a focus on simulating the electrical properties and excitability of these neurons in a manner consistent with biological reality.
Fast Na+ and Persistent Na+ Currents:
K+ Currents:
Leakage Currents (Il):
HCN Channels (Ih or Iq):
The code follows principles from the Hodgkin-Huxley framework, utilizing gating variables (m, h, n) to describe the probability of ion channel states (open, closed). Here, gating variables s
, q
, and n
describe the activation states of the slow K+, HCN, and fast K+ channels, respectively. These variables follow first-order kinetics influenced by voltage-dependent rate constants.
The model incorporates Q10 coefficients to account for temperature-dependent rates of ion channel kinetics, reflecting that biological processes can speed up or slow down with temperature changes.
The model aims to simulate and understand the behavior of sensory axons under physiological conditions, focusing on ion channel dynamics essential for sensory signal transmission. By considering various ion channel types, gating dynamics, temperature effects, and reversal potentials, the model attempts to capture the complex electrical characteristics of sensory neurons, aiding in insights into their physiological and pathological conditions.
Overall, this code represents an advanced simulation model that captures crucial aspects of neuronal excitability, specific to sensory axons in the median nerve, through the inclusion of multiple ionic currents characterized by biologically plausible parameters.