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Biological Basis of the Modified Morris-Lecar Model

The provided code models the electrophysiological behavior of neurons with a focus on ionic currents responsible for action potential generation and propagation. Specifically, it is a modification of the Morris-Lecar model, enhanced with a variable T-type calcium current, drawing on work by Prescott and Rubin. Here are the key biological aspects modeled by this code:

Ionic Currents

Fast Sodium Current (INa)

Delayed Rectifier Potassium Current (IKdr)

Leak Current (Il)

T-type Calcium Current (IT)

Other Biological Aspects

Summary

This model combines fast sodium, delayed rectifier potassium, leak, and T-type calcium currents to simulate the complex behavior of neuronal action potentials and firing patterns. By incorporating noise and parameters for external stimuli, it reflects realistic neuronal dynamics within a computational framework, providing insights into the interplay between different ionic currents and their contribution to neuronal excitability and signaling.