Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)

This NEURON code implements a small network model (100 pyramidal cells and 4 types of inhibitory interneuron) of storage and recall of patterns in the CA1 region of the mammalian hippocampus. Patterns of PC activity are stored either by a predefined weight matrix generated by Hebbian learning, or by STDP at CA3 Schaffer collateral AMPA synapses.

Model Type: Realistic Network

Region(s) or Organism(s): Hippocampus

Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 basket cell

Receptors: GabaA; AMPA; NMDA

Model Concept(s): Pattern Recognition; Activity Patterns; Temporal Pattern Generation; Learning; STDP; Connectivity matrix; Storage/recall

Simulation Environment: NEURON

Implementer(s): Graham, Bruce [B.Graham at cs.stir.ac.uk]; Cutsuridis, Vassilis [vcutsuridis at gmail.com]

References:

Cutsuridis V, Cobb S, Graham BP. (2010). Encoding and retrieval in a model of the hippocampal CA1 microcircuit. Hippocampus. 20 [PubMed]