" ... During the acute-stage of spinal cord injury (SCI), the endogenous ability to generate plateaus is lost; however, during the chronic-stage of SCI, plateau potentials reappear with prolonged self-sustained firing that has been implicated in the development of spasticity. In this work, we extend previous modeling studies to systematically investigate the mechanisms underlying the generation of plateau potentials in motoneurons, including the influences of specific ionic currents, the morphological characteristics of the soma and dendrite, and the interactions between persistent inward currents and synaptic input. ..."
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Spinal motoneuron
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell
Currents: I Na,p; I K,Ca; I CAN; I Sodium; I Potassium; I Ca,p
Model Concept(s): Simplified Models; Active Dendrites; Intrinsic plasticity; Synaptic Integration
Simulation Environment: XPPAUT; MATLAB
Implementer(s): Kurian, Mini ; Crook, Sharon
References:
Kurian M, Crook SM, Jung R. (2011). Motoneuron model of self-sustained firing after spinal cord injury. Journal of computational neuroscience. 31 [PubMed]