Neurophysiological impact of inactivation pathways in A-type K+ channels (Fineberg et al 2012)

These models predict the differential effects of varying pathways of inactivation (closed state inactivation, CSI, or open state inactivation, OSI). Specifically, Markov models of Kv4 potassium channels with CSI or CSI+OSI were inserted into the CA1 pyramidal neuron model from Migliore et al (1999; ModelDB accession #2796) to determine the neurophysiological impact of inactivation pathways. Furthermore, Markov models of Kv4.2 and Kv3.4 channels are used to illustrate a method by which to test what pathway of inactivation a channel uses.

Model Type: Neuron or other electrically excitable cell; Channel/Receptor

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Currents: I Na,t; I A; I K

Genes: Kv4.2 KCND2; Kv3.4 KCNC4

Model Concept(s): Ion Channel Kinetics; Markov-type model

Simulation Environment: NEURON; IonChannelLab

Implementer(s): Ritter, David [david.ritter at jefferson.edu]

References:

Fineberg JD, Ritter DM, Covarrubias M. (2012). Modeling-independent elucidation of inactivation pathways in recombinant and native A-type Kv channels. The Journal of general physiology. 140 [PubMed]