A set of reduced models of layer 5 pyramidal neurons (Bahl et al. 2012)

These are the NEURON files for 10 different models of a reduced L5 pyramidal neuron. The parameters were obtained by automatically fitting the models to experimental data using a multi objective evolutionary search strategy. Details on the algorithm can be found at http://www.g-node.org/emoo and in Bahl et al. (2012).

Model Type: Neuron or other electrically excitable cell; Dendrite

Cell Type(s): Neocortex U1 L5B pyramidal pyramidal tract GLU cell

Currents: I Na,p; I Na,t; I K; I M; I h; I K,Ca; I Calcium; I A, slow

Model Concept(s): Action Potential Initiation; Parameter Fitting; Simplified Models; Active Dendrites; Detailed Neuronal Models; Action Potentials; Methods; Calcium dynamics

Simulation Environment: NEURON

Implementer(s): Bahl, Armin [bahl at neuro.mpg.de]

References:

Bahl A, Stemmler MB, Herz AV, Roth A. (2012). Automated optimization of a reduced layer 5 pyramidal cell model based on experimental data. Journal of neuroscience methods. 210 [PubMed]