"... Here we introduce a new, automatic and fast method to map realistic neurons into equivalent reduced models running up to >40 times faster while maintaining a very high accuracy of the membrane potential dynamics during synaptic inputs, and a direct link with experimental observables. The mapping of arbitrary sets of synaptic inputs, without additional fine tuning, would also allow the convenient and efficient implementation of a new generation of large-scale simulations of brain regions reproducing the biological variability observed in real neurons, with unprecedented advances to understand higher brain functions."
Model Type: Dendrite
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I Na,t; I A; I K; I h
Receptors: AMPA
Model Concept(s): Simplified Models; Detailed Neuronal Models
Simulation Environment: NEURON
Implementer(s): Limongiello, Alessandro [alessandro.limongiello at unina.it]
References:
Marasco A, Limongiello A, Migliore M. (2012). Fast and accurate low-dimensional reduction of biophysically detailed neuron models. Scientific reports. 2 [PubMed]