Large-scale model of neocortical slice in vitro exhibiting persistent gamma (Tomsett et al. 2014)


This model contains 15 neuron populations (8 excitatory, 7 inhibitory) arranged into 4 cortical layers (layer 1 empty, layers 2/3 combined). It produces a persistent gamma oscillation driven by layer 2/3. It runs using the VERTEX simulator, which is written in Matlab and is available from http://www.vertexsimulator.org

Model Type: Realistic Network; Extracellular

Region(s) or Organism(s): Neocortex

Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Neocortex V1 interneuron basket PV GABA cell; Neocortex fast spiking (FS) interneuron; Neocortex spiny stellate cell; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron; Abstract integrate-and-fire adaptive exponential (AdEx) neuron

Currents: I_AHP

Receptors: GabaA; AMPA

Transmitters: Gaba; Glutamate

Model Concept(s): Brain Rhythms; Gamma oscillations

Simulation Environment: VERTEX

Implementer(s): Tomsett, Richard [r at autap.se]

References:

Tomsett RJ et al. (2015). Virtual Electrode Recording Tool for EXtracellular potentials (VERTEX): comparing multi-electrode recordings from simulated and biological mammalian cortical tissue. Brain structure & function. 220 [PubMed]


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