We developed a novel multiscale model to bridge neuropeptide receptor-activated signaling pathway with membrane electrophysiology. The model studies the effects of Angiotensin II (AngII) on neuronal excitability changes mediated by signaling dynamics and downstream phosphorylation of ion channels. The multiscale model was implemented as a set of ordinary differential equations solved using the ode15s solver in Matlab (Mathworks, USA). The signaling reactions were modeled with either mass-action or Michaelis--Menten kinetics and ion channel electrophysiology was modeled according to the Hodgkin-Huxley formalism. These models were initially validated against their respective data domains independently and were integrated to develop a multiscale model of signaling and electrophysiology.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Brainstem
Model Concept(s): Signaling pathways; Calcium dynamics; Neuromodulation; Multiscale
Simulation Environment: MATLAB
Implementer(s): Makadia, Hirenkumar K [hiren.makadia at gmail.com]; Anderson, Warren D [warren.anderson at jefferson.edu]; Fey, Dirk [dirk.fey at ucd.ie]; Vadigepalli, Rajanikanth [Rajanikanth.Vadigepalli at jefferson.edu]
References:
Makadia HK et al. (2015). Multiscale model of dynamic neuromodulation integrating neuropeptide-induced signaling pathway activity with membrane electrophysiology. Biophysical journal. 108 [PubMed]