Firing neocortical layer V pyramidal neuron (Reetz et al. 2014; Stadler et al. 2014)

Neocortical Layer V model with firing behaviour adjusted to in vitro observations. The model was used to investigate the effects of IFN and PKC on the excitability of neurons (Stadler et al 2014, Reetz et al. 2014). The model contains new channel simulations for HCN1, HCN2 and the big calcium dependent potassium channel BK.

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Neocortex

Cell Type(s): Neocortex L5/6 pyramidal GLU cell

Currents: I Na,p; I Na,t; I L high threshold; I A; I K; I M; I h; I K,Ca; I Sodium; I Calcium; I Mixed; I Potassium; I Q

Genes: HCN1; HCN2

Model Concept(s): Activity Patterns; Detailed Neuronal Models; Action Potentials; Signaling pathways

Simulation Environment: NEURON

Implementer(s): Stadler, Konstantin [konstantin.stadler at ntnu.no]

References:

Stadler K et al. (2014). Elevation in type I interferons inhibits HCN1 and slows cortical neuronal oscillations. Cerebral cortex (New York, N.Y. : 1991). 24 [PubMed]

Reetz O, Stadler K, Strauss U. (2014). Protein kinase C activation mediates interferon-ß-induced neuronal excitability changes in neocortical pyramidal neurons. Journal of neuroinflammation. 11 [PubMed]