Glutamatergic transmission at a principal neuron-interneuron synapse was investigated by dual whole-cell patch-clamp recording in rat hippocampal slices combined with morphological analysis and modeling. Simulations based on a compartmental model of the interneuron indicated that the rapid postsynaptic conductance change determines the shape and the somatodendritic integration of EPSPs, thus enabling interneurons to detect synchronous principal neuron activity.
Model Type: Synapse
Receptors: AMPA
Transmitters: Glutamate
Model Concept(s): Influence of Dendritic Geometry; Detailed Neuronal Models
Simulation Environment: NEURON
Implementer(s): Roth, Arnd
References:
Geiger JR, Lübke J, Roth A, Frotscher M, Jonas P. (1997). Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse. Neuron. 18 [PubMed]