Mechanisms of fast rhythmic bursting in a layer 2/3 cortical neuron (Traub et al 2003)

This simulation is based on the reference paper listed below. This port was made by Roger D Traub and Maciej T Lazarewicz (mlazarew at seas.upenn.edu) Thanks to Ashlen P Reid for help with porting a morphology of the cell.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Neocortex L2/3 pyramidal GLU cell

Currents: I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I K,Ca; I Sodium; I Calcium; I Potassium

Model Concept(s): Dendritic Action Potentials; Bursting; Active Dendrites; Detailed Neuronal Models; Axonal Action Potentials; Calcium dynamics

Simulation Environment: NEURON

Implementer(s): Lazarewicz, Maciej [mlazarew at gmu.edu]; Traub, Roger D [rtraub at us.ibm.com]

References:

Traub RD, Buhl EH, Gloveli T, Whittington MA. (2003). Fast rhythmic bursting can be induced in layer 2/3 cortical neurons by enhancing persistent Na+ conductance or by blocking BK channels. Journal of neurophysiology. 89 [PubMed]