A NN with synaptic depression for testing the effects of connectivity on dynamics (Jacob et al 2019)

Here we used a 10,000 neuron model. The neurons are a mixture of excitatory and inhibitory integrate-and-fire neurons connected with synapses that exhibit synaptic depression. Three different connectivity paradigms were tested to look for spontaneous transition between interictal spiking and seizure: uniform, small-world network, and scale-free. All three model types are included here.

Model Type: Connectionist Network

Region(s) or Organism(s): Mouse; Hippocampus

Cell Type(s): Abstract integrate-and-fire neuron

Currents: I_K,Na

Receptors: GabaA; Glutamate

Transmitters: Gaba; Glutamate

Model Concept(s): Connectivity matrix; Epilepsy

Simulation Environment: C or C++ program

Implementer(s): Jacob, Theju

References:

Jacob T et al. (2019). A Proposed Mechanism for Spontaneous Transitions between Interictal and Ictal Activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 39 [PubMed]