Fhf2WT and Fhf2KO mouse ventricular cardiomyocyte models differ only in the inactivation gating of voltage-gated sodium channels. Cardiomyocyte linear strands were constructed by electrically coupling 111 model cells. Action potential conduction through the Fhf2KO strand is blocked by a range of stressors, including temperature elevation or reduction in sodium, calcium, or gap junctional conductance densities. Conduction through the Fhf2WT model strand is resistant to these stresses.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Cardiac ventricular cell
Currents: I K; Na/K pump; I L high threshold; I Na,t
Model Concept(s): Conduction failure; Detailed Neuronal Models; Heart disease; Ion Channel Kinetics; Temperature
Simulation Environment: NEURON
Implementer(s): Goldfarb, Mitchell goldfarb at genectr.hunter.cuny.edu]; Solinas, Sergio [solinas at unipv.it]
References:
Park DS et al. (2020). Ionic Mechanisms of Impulse Propagation Failure in the FHF2-Deficient Heart. Circulation research. 127 [PubMed]