We create multi-compartment models of an Oriens-Lacunosum/Moleculare (O-LM) hippocampal interneuron using passive properties, channel kinetics, densities and distributions specific to this cell type, and explore its signaling characteristics. We find that spike initiation depends on both location and amount of input, as well as the intrinsic properties of the interneuron. Distal synaptic input always produces strong back-propagating spikes whereas proximal input could produce both forward and back-propagating spikes depending on the input strength. Please see paper for more details.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Hippocampus CA1 interneuron oriens alveus GABA cell
Currents: I Na,t; I A; I K; I h
Receptors: AMPA
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials
Simulation Environment: NEURON
Implementer(s): Saraga, Fernanda [Fernanda.Saraga at utoronto.ca]
References:
Saraga F, Wu CP, Zhang L, Skinner FK. (2003). Active dendrites and spike propagation in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons. The Journal of physiology. 552 [PubMed]