Cortical network model of posttraumatic epileptogenesis (Bush et al 1999)

This simulation from Bush, Prince, and Miller 1999 shows the epileptiform response (Fig. 6C) to a brief single stimulation in a 500 cell network of multicompartment models, some of which have active dendrites. The results which I obtained under Redhat Linux is shown in result.gif. Original 1997 code from Paul Bush modified slightly by Bill Lytton to make it work with current version of NEURON (5.7.139). Thanks to Paul Bush and Ken Miller for making the code available.

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Neocortex

Cell Type(s): Neocortex M1 L5B pyramidal pyramidal tract GLU cell; Neocortex M1 L2/6 pyramidal intratelencephalic GLU cell; Neocortex M1 interneuron basket PV GABA cell

Currents: I Na,t; I Sodium; I Potassium

Receptors: GabaA; GabaB; AMPA; NMDA; Gaba

Transmitters: Gaba; Glutamate

Model Concept(s): Active Dendrites; Detailed Neuronal Models; Epilepsy; Synaptic Integration

Simulation Environment: NEURON

Implementer(s): Lytton, William [bill.lytton at downstate.edu]; Bush, Paul

References:

Bush PC, Prince DA, Miller KD. (1999). Increased pyramidal excitability and NMDA conductance can explain posttraumatic epileptogenesis without disinhibition: a model. Journal of neurophysiology. 82 [PubMed]