"The biophysical properties of neuron R15 in Aplysia endow it with the ability to express multiple modes of oscillatory electrical activity, such as beating and bursting. Previous modeling studies examined the ways in which membrane conductances contribute to the electrical activity of R15 and the ways in which extrinsic modulatory inputs alter the membrane conductances by biochemical cascades and influence the electrical activity. The goals of the present study were to examine the ways in which electrical activity influences the biochemical cascades and what dynamical properties emerge from the ongoing interactions between electrical activity and these cascades." See paper for more and details.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Aplysia R15 bursting neuron
Currents: I Na,p; I Na,t; I N; I A; I K; I h; I K,Ca; I Sodium; I Calcium; I Potassium; I A, slow
Receptors: D1; D2; 5-HT1; 5-HT2; 5-HT4; 5-HT3; Dopaminergic Receptor
Transmitters: Dopamine; Serotonin
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Ion Channel Kinetics; Oscillations; Detailed Neuronal Models; Action Potentials; Invertebrate
Simulation Environment: XPPAUT
References:
Yu X, Byrne JH, Baxter DA. (2004). Modeling interactions between electrical activity and second-messenger cascades in Aplysia neuron R15. Journal of neurophysiology. 91 [PubMed]