Doron M, Chindemi G, Muller E, Markram H, Segev I. (2017). Timed Synaptic Inhibition Shapes NMDA Spikes, Influencing Local Dendritic Processing and Global I/O Properties of Cortical Neurons. Cell reports. 21 [PubMed]

See more from authors: Doron M · Chindemi G · Muller E · Markram H · Segev I

References and models cited by this paper

Bar-Ilan L, Gidon A, Segev I. (2012). The role of dendritic inhibition in shaping the plasticity of excitatory synapses. Frontiers in neural circuits. 6 [PubMed]

Branco T, Clark BA, Häusser M. (2010). Dendritic discrimination of temporal input sequences in cortical neurons. Science (New York, N.Y.). 329 [PubMed]

Branco T, Häusser M. (2011). Synaptic integration gradients in single cortical pyramidal cell dendrites. Neuron. 69 [PubMed]

Brandalise F, Carta S, Helmchen F, Lisman J, Gerber U. (2016). Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells. Nature communications. 7 [PubMed]

Chiu CQ et al. (2013). Compartmentalization of GABAergic inhibition by dendritic spines. Science (New York, N.Y.). 340 [PubMed]

Clarke RJ, Johnson JW. (2008). Voltage-dependent gating of NR1/2B NMDA receptors. The Journal of physiology. 586 [PubMed]

Du K et al. (2017). Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons. Proceedings of the National Academy of Sciences of the United States of America. 114 [PubMed]

Gambino F et al. (2014). Sensory-evoked LTP driven by dendritic plateau potentials in vivo. Nature. 515 [PubMed]

Gidon A, Segev I. (2012). Principles governing the operation of synaptic inhibition in dendrites. Neuron. 75 [PubMed]

Golding NL, Staff NP, Spruston N. (2002). Dendritic spikes as a mechanism for cooperative long-term potentiation. Nature. 418 [PubMed]

Gordon U, Polsky A, Schiller J. (2006). Plasticity compartments in basal dendrites of neocortical pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Graupner M, Brunel N. (2012). Calcium-based plasticity model explains sensitivity of synaptic changes to spike pattern, rate, and dendritic location. Proceedings of the National Academy of Sciences of the United States of America. 109 [PubMed]

Grunditz A, Holbro N, Tian L, Zuo Y, Oertner TG. (2008). Spine neck plasticity controls postsynaptic calcium signals through electrical compartmentalization. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Hay E, Hill S, Schürmann F, Markram H, Segev I. (2011). Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties. PLoS computational biology. 7 [PubMed]

Higley MJ. (2014). Localized GABAergic inhibition of dendritic Ca(2+) signalling. Nature reviews. Neuroscience. 15 [PubMed]

Hines ML, Carnevale NT. (2006). The NEURON Book.

Hoffman DA, Magee JC, Colbert CM, Johnston D. (1997). K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature. 387 [PubMed]

Iacaruso MF, Gasler IT, Hofer SB. (2017). Synaptic organization of visual space in primary visual cortex. Nature. 547 [PubMed]

Jadi M, Polsky A, Schiller J, Mel BW. (2012). Location-dependent effects of inhibition on local spiking in pyramidal neuron dendrites. PLoS computational biology. 8 [PubMed]

Jahr CE, Stevens CF. (1990). Voltage dependence of NMDA-activated macroscopic conductances predicted by single-channel kinetics. The Journal of neuroscience : the official journal of the Society for Neuroscience. 10 [PubMed]

Johnston D, Narayanan R. (2008). Active dendrites: colorful wings of the mysterious butterflies. Trends in neurosciences. 31 [PubMed]

Kampa BM, Clements J, Jonas P, Stuart GJ. (2004). Kinetics of Mg2+ unblock of NMDA receptors: implications for spike-timing dependent synaptic plasticity. The Journal of physiology. 556 [PubMed]

Kantevari S, Matsuzaki M, Kanemoto Y, Kasai H, Ellis-Davies GC. (2010). Two-color, two-photon uncaging of glutamate and GABA. Nature methods. 7 [PubMed]

Klausberger T. (2009). GABAergic interneurons targeting dendrites of pyramidal cells in the CA1 area of the hippocampus. The European journal of neuroscience. 30 [PubMed]

Larkum ME, Nevian T. (2008). Synaptic clustering by dendritic signalling mechanisms. Current opinion in neurobiology. 18 [PubMed]

Larkum ME, Zhu JJ, Sakmann B. (1999). A new cellular mechanism for coupling inputs arriving at different cortical layers. Nature. 398 [PubMed]

Lavzin M, Rapoport S, Polsky A, Garion L, Schiller J. (2012). Nonlinear dendritic processing determines angular tuning of barrel cortex neurons in vivo. Nature. 490 [PubMed]

Lovett-Barron M et al. (2012). Regulation of neuronal input transformations by tunable dendritic inhibition. Nature neuroscience. 15 [PubMed]

Ma WP et al. (2010). Visual representations by cortical somatostatin inhibitory neurons--selective but with weak and delayed responses. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30 [PubMed]

Magee JC. (2016). Dendritic voltage-gated ion channels Dendrites.

Major G, Larkum ME, Schiller J. (2013). Active properties of neocortical pyramidal neuron dendrites. Annual review of neuroscience. 36 [PubMed]

Major G, Polsky A, Denk W, Schiller J, Tank DW. (2008). Spatiotemporally graded NMDA spike/plateau potentials in basal dendrites of neocortical pyramidal neurons. Journal of neurophysiology. 99 [PubMed]

Markram H et al. (2004). Interneurons of the neocortical inhibitory system. Nature reviews. Neuroscience. 5 [PubMed]

Mel BW. (1992). NMDA-based pattern discrimination in a modeled cortical neuron. Neural Comput. 4

Mel BW. (1993). Synaptic integration in an excitable dendritic tree. Journal of neurophysiology. 70 [PubMed]

Milojkovic BA, Radojicic MS, Goldman-Rakic PS, Antic SD. (2004). Burst generation in rat pyramidal neurones by regenerative potentials elicited in a restricted part of the basilar dendritic tree. The Journal of physiology. 558 [PubMed]

Mizuseki K, Sirota A, Pastalkova E, Buzsáki G. (2009). Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop. Neuron. 64 [PubMed]

Moradi K et al. (2013). A fast model of voltage-dependent NMDA receptors. Journal of computational neuroscience. 34 [PubMed]

Müllner FE, Wierenga CJ, Bonhoeffer T. (2015). Precision of Inhibition: Dendritic Inhibition by Individual GABAergic Synapses on Hippocampal Pyramidal Cells Is Confined in Space and Time. Neuron. 87 [PubMed]

Nevian T, Larkum ME, Polsky A, Schiller J. (2007). Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study. Nature neuroscience. 10 [PubMed]

Palmer LM et al. (2014). NMDA spikes enhance action potential generation during sensory input. Nature neuroscience. 17 [PubMed]

Poirazi P, Brannon T, Mel BW. (2003). Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron. 37 [PubMed]

Poirazi P, Brannon T, Mel BW. (2003). Pyramidal neuron as two-layer neural network. Neuron. 37 [PubMed]

Poirazi P, Mel BW. (2001). Impact of active dendrites and structural plasticity on the memory capacity of neural tissue. Neuron. 29 [PubMed]

Poleg-Polsky A. (2015). Effects of Neural Morphology and Input Distribution on Synaptic Processing by Global and Focal NMDA-Spikes. PloS one. 10 [PubMed]

Polsky A, Mel B, Schiller J. (2009). Encoding and decoding bursts by NMDA spikes in basal dendrites of layer 5 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Pouille F, Scanziani M. (2001). Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition. Science (New York, N.Y.). 293 [PubMed]

Pérez-Garci E, Larkum ME, Nevian T. (2013). Inhibition of dendritic Ca2+ spikes by GABAB receptors in cortical pyramidal neurons is mediated by a direct Gi/o-ß-subunit interaction with Cav1 channels. The Journal of physiology. 591 [PubMed]

Rall W, Shepherd GM. (1968). Theoretical reconstruction of field potentials and dendrodendritic synaptic interactions in olfactory bulb. Journal of neurophysiology. 31 [PubMed]

Rall W, Shepherd GM, Reese TS, Brightman MW. (1966). Dendrodendritic synaptic pathway for inhibition in the olfactory bulb. Experimental neurology. 14 [PubMed]

Remme MWH, Cuntz H, Torben-Nielsen B. (2013). The Computing Dendrite: From Structure to Function.

Rhodes P. (2006). The properties and implications of NMDA spikes in neocortical pyramidal cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Royer S et al. (2012). Control of timing, rate and bursts of hippocampal place cells by dendritic and somatic inhibition. Nature neuroscience. 15 [PubMed]

Salin PA, Prince DA. (1996). Spontaneous GABAA receptor-mediated inhibitory currents in adult rat somatosensory cortex. Journal of neurophysiology. 75 [PubMed]

Sanders H, Berends M, Major G, Goldman MS, Lisman JE. (2013). NMDA and GABAB (KIR) conductances: the "perfect couple" for bistability. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33 [PubMed]

Sandler M, Shulman Y, Schiller J. (2016). A Novel Form of Local Plasticity in Tuft Dendrites of Neocortical Somatosensory Layer 5 Pyramidal Neurons. Neuron. 90 [PubMed]

Schiller J, Major G, Koester HJ, Schiller Y. (2000). NMDA spikes in basal dendrites of cortical pyramidal neurons. Nature. 404 [PubMed]

Schiller J, Schiller Y. (2001). NMDA receptor-mediated dendritic spikes and coincident signal amplification. Current opinion in neurobiology. 11 [PubMed]

Segev I, Rall W. (1988). Computational study of an excitable dendritic spine. Journal of neurophysiology. 60 [PubMed]

Segev I, Yarom Y, Rapp M. (1992). The impact of parallel fiber background activity on the cable properties of cerebellar Purkinje cells Neural Comput. 4

Shouval HZ, Bear MF, Cooper LN. (2002). A unified model of NMDA receptor-dependent bidirectional synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America. 99 [PubMed]

Silberberg G, Markram H. (2007). Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells. Neuron. 53 [PubMed]

Smith SL, Smith IT, Branco T, Häusser M. (2013). Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo. Nature. 503 [PubMed]

Spruston N, Jonas P, Sakmann B. (1995). Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons. The Journal of physiology. 482 ( Pt 2) [PubMed]

Stokes CC, Teeter CM, Isaacson JS. (2014). Single dendrite-targeting interneurons generate branch-specific inhibition. Frontiers in neural circuits. 8 [PubMed]

Tsien RW, Noble D, Jack JJB. (1975). Electric Current Flow in Excitable Cells.

Vargas-Caballero M, Robinson HP. (2004). Fast and slow voltage-dependent dynamics of magnesium block in the NMDA receptor: the asymmetric trapping block model. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Villa KL et al. (2016). Inhibitory Synapses Are Repeatedly Assembled and Removed at Persistent Sites In Vivo. Neuron. 89 [PubMed]

Wehr M, Zador AM. (2003). Balanced inhibition underlies tuning and sharpens spike timing in auditory cortex. Nature. 426 [PubMed]

Wilmes KA, Sprekeler H, Schreiber S. (2016). Inhibition as a Binary Switch for Excitatory Plasticity in Pyramidal Neurons. PLoS computational biology. 12 [PubMed]

Wilson DE, Whitney DE, Scholl B, Fitzpatrick D. (2016). Orientation selectivity and the functional clustering of synaptic inputs in primary visual cortex. Nature neuroscience. 19 [PubMed]

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