This model was implemented by Rob Morgan in the Soltesz lab at UC Irvine. It is a scaleable model of the rat dentate gyrus including four cell types. This model runs in serial (on a single processor) and has been published at the size of 50,000 granule cells (with proportional numbers of the other cells).
Model Type: Realistic Network
Region(s) or Organism(s): Dentate gyrus
Model Concept(s): Epilepsy
Simulation Environment: NEURON
Santhakumar V, Aradi I, Soltesz I. (2005). Role of mossy fiber sprouting and mossy cell loss in hyperexcitability: a network model of the dentate gyrus incorporating cell types and axonal topography. J Neurophysiol 93 [PubMed]
Dyhrfjeld-johnsen J, Santhakumar V, Morgan RJ, Huerta R, Tsimring L, Soltesz I. (2007). Topological determinants of epileptogenesis in large-scale structural and functional models of the dentate gyrus derived from experimental data. J Neurophysiol 97 [PubMed]