Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)


This model was implemented by Rob Morgan in the Soltesz lab at UC Irvine. It is a scaleable model of the rat dentate gyrus including four cell types. This model runs in serial (on a single processor) and has been published at the size of 50,000 granule cells (with proportional numbers of the other cells).

Model Type: Realistic Network

Region(s) or Organism(s): Dentate gyrus

Cell Type(s): Dentate gyrus granule GLU cell; Dentate gyrus mossy cell; Dentate gyrus basket cell; Dentate gyrus hilar cell

Model Concept(s): Epilepsy

Simulation Environment: NEURON

Implementer(s): Bezaire, Marianne [mariannejcase at gmail.com]; Morgan, Robert [polomav at gmail.com]

References:

Santhakumar V, Aradi I, Soltesz I. (2005). Role of mossy fiber sprouting and mossy cell loss in hyperexcitability: a network model of the dentate gyrus incorporating cell types and axonal topography. J Neurophysiol 93 [PubMed]

Dyhrfjeld-johnsen J, Santhakumar V, Morgan RJ, Huerta R, Tsimring L, Soltesz I. (2007). Topological determinants of epileptogenesis in large-scale structural and functional models of the dentate gyrus derived from experimental data. J Neurophysiol 97 [PubMed]

Morgan RJ, Soltesz I. (2008). Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures. Proc Natl Acad Sci U S A 105 [PubMed]

Morgan RJ, Santhakumar V, Soltesz I. (2007). Modeling the dentate gyrus. Prog Brain Res 163 [PubMed]