Exploring the kinetics and distribution of the muscarinic potassium channel, IM, in 2 O-LM interneuron morphologies. Modulation of the ion channel by drugs such as XE991 (antagonist) and retigabine (agonist) are simulated in the models to examine the role of IM in spiking properties.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Hippocampus CA1 interneuron oriens alveus GABA cell
Currents: I L high threshold; I N; I T low threshold; I A; I K; I K,leak; I M; I h; I K,Ca
Receptors: Muscarinic
Model Concept(s): Ion Channel Kinetics; Oscillations; Detailed Neuronal Models; Action Potentials
Simulation Environment: NEURON
References:
Lawrence JJ et al. (2006). Somatodendritic Kv7/KCNQ/M channels control interspike interval in hippocampal interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]