" ... We propose here a mathematical model of how spontaneous Ca2+ oscillations arise in astrocytes. This model uses the calcium-induced calcium release and inositol cross-coupling mechanisms coupled with a receptor-independent method for producing inositol (1,4,5)-trisphosphate as the heart of the model. By computationally mimicking experimental constraints we have found that this model provides results that are qualitatively similar to experiment."
Model Type: Electrogenic pump; Glia
Cell Type(s): Astrocyte
Receptors: IP3
Transmitters: Ions
Model Concept(s): Oscillations; Simplified Models; Signaling pathways; Calcium dynamics; Calcium waves
Simulation Environment: XPPAUT
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]
References:
Lavrentovich M, Hemkin S. (2008). A mathematical model of spontaneous calcium(II) oscillations in astrocytes. Journal of theoretical biology. 251 [PubMed]