Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)

"We describe a computational model of the principal cell in the nucleus accumbens (NAcb), the medium spiny projection (MSP) neuron. The model neuron, constructed in NEURON, includes all of the known ionic currents in these cells and receives synaptic input from simulated spike trains via NMDA, AMPA, and GABAA receptors. ... results suggest that afferent information integration by the NAcb MSP cell may be compromised by pathology in which the NMDA current is altered or modulated, as has been proposed in both schizophrenia and addiction."

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Nucleus accumbens spiny projection neuron

Currents: I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I A; I h; I K,Ca; I Krp; I R; I Q

Receptors: GabaA; AMPA; NMDA

Model Concept(s): Oscillations; Schizophrenia; Addiction

Simulation Environment: NEURON

Implementer(s): Wolf, John A. [johnwolf at warpmail.net]; Moyer, Jason [jtmoyer at seas.upenn.edu]

References:

Wolf JA et al. (2005). NMDA/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]