"We describe a new molecular mechanism of dopamine-induced membrane protein modulation that can tune neuronal oscillation frequency to attention related gamma rhythm. This mechanism is based on the unique ability of D4 dopamine receptors (D4R) to carry out phospholipid methylation (PLM) that may affect the kinetics of ion channels. We show that by deceasing the inertia of the delayed rectifier potassium channel, a transition to 40 Hz oscillations can be achieved. ..."
Model Type: Realistic Network; Neuron or other electrically excitable cell; Synapse
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell
Currents: I Na,t; I T low threshold; I K; I K,Ca
Transmitters: Dopamine
Model Concept(s): Activity Patterns; Oscillations; Synchronization; Simplified Models; Signaling pathways
Simulation Environment: XPPAUT
Implementer(s): Kuznetsova, Anna [anna.kuznetsova at utsa.edu]
References:
Kuznetsova AY, Deth RC. (2008). A model for modulation of neuronal synchronization by D4 dopamine receptor-mediated phospholipid methylation. Journal of computational neuroscience. 24 [PubMed]