"... The effects of propofol, an intravenous anesthetic agent with a distinct chemical structure, on ion currents of differentiated clonal cardiac (H9c2) cells were investigated in this study. Propofol ... suppressed the amplitude of delayed rectifier K(+) current (I(K(DR))) in a concentration-dependent manner with an IC(50) value of 36 muM. ... Propofol (30 muM) had no effect on erg-mediated K(+) current in these cells; however, it suppressed L-type Ca(2+) current (I(Ca,L)) of cardiac and skeletal types to a similar extent. ... Numerical simulations of I(K(DR)) based on a Markovian model reproduce the experimental results and show that propofol-induced blockade of I(K(DR)) is associated with an decrease in forward rate of the activation process and an increase in transitional rate into the inactivated state. ..."
Model Type: Channel/Receptor
Cell Type(s): Heart cell
Currents: I Potassium; I_Ks
Model Concept(s): Ion Channel Kinetics; Heart disease
Simulation Environment: XPPAUT
References:
Liu YC, Wang YJ, Wu SN. (2008). The mechanisms of propofol-induced block on ion currents in differentiated H9c2 cardiac cells. European journal of pharmacology. 590 [PubMed]