Quantal neurotransmitter release kinetics with fixed and mobile Ca2+ buffers (Gilmanov et al. 2008)


"... In this work, we used computer modeling of quanta release kinetics with various levels of calcium influx and in the presence of endogenous calcium buffers with varying mobilities. The results of this modeling revealed the desynchronization of quanta release under low calcium influx in the presence of an endogenous fixed calcium buffer, with a diffusion coefficient much smaller than that of free Ca2+, and synchronization occurred upon adding a mobile buffer. This corresponds to changes in secretion time course parameters found experimentally ..."

Model Type: Neuromuscular Junction

Model Concept(s): Calcium dynamics

Simulation Environment: Pascal (web link to model)

References:

Gilmanov IR, Samigullin DV, Vyskocil F, Nikolsky EE, Bukharaeva EA. (2008). Modeling of quantal neurotransmitter release kinetics in the presence of fixed and mobile calcium buffers. J Comput Neurosci 25 [PubMed]