Permeation and inactivation of CaV1.2 Ca2+ channels (Babich et al. 2007)


The authors present data and a kinetics model of the CaV1.2 channel supporting the idea that Ca2+ block of the pore generates the U-shaped inactivation curve.

Model Type: Channel/Receptor

Currents: I L high threshold

Model Concept(s): Ion Channel Kinetics

Simulation Environment: CalC Calcium Calculator (web link to model)

References:

Babich O, Matveev V, Harris AL, Shirokov R. (2007). Ca2+-dependent inactivation of CaV1.2 channels prevents Gd3+ block: does Ca2+ block the pore of inactivated channels? The Journal of general physiology. 129 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.