New and corrected simulations of synaptic facilitation (Matveev et al. 2002)


"A three-dimensional presynaptic calcium diffusion model developed to account for characteristics of transmitter release was modified to provide for binding of calcium to a receptor and subsequent triggering of exocytosis. When low affinity (20 FLM) and rapid kinetics were assumed for the calcium receptor triggering exocytosis, and stimulus parameters were selected to match those of experiments, the simulations predicted a virtual invariance of the time course of transmitter release to paired stimulation, stimulation with pulses of different amplitude, and stimulation in different calcium solutions. ..."

Model Type: Molecular Network

Model Concept(s): Facilitation; Calcium dynamics

Simulation Environment: CalC Calcium Calculator (web link to model)

Implementer(s): Matveev, Victor V. [m a t v e e v at n j i t . e d u ]

References:

Matveev V, Sherman A, Zucker RS. (2002). New and corrected simulations of synaptic facilitation. Biophys J 83 [PubMed]