TTX-R Na+ current effect on cell response (Herzog et al 2001) (MATLAB)


"Small dorsal root ganglion (DRG) neurons, which include nociceptors, express multiple voltage-gated sodium currents. In addition to a classical fast inactivating tetrodotoxin-sensitive (TTX-S) sodium current, many of these cells express a TTX-resistant (TTX-R) sodium current that activates near -70 mV and is persistent at negative potentials. To investigate the possible contributions of this TTX-R persistent (TTX-RP) current to neuronal excitability, we carried out computer simulations using the Neuron program with TTX-S and -RP currents, fit by the Hodgkin-Huxley model, that closely matched the currents recorded from small DRG neurons. ..." See paper for more and details.

Model Type: Neuron or other electrically excitable cell

Currents: I Na,p; I Na,t; I K

Model Concept(s): Ion Channel Kinetics; Nociception

Simulation Environment: MATLAB

Implementer(s): Andersson, Thomas [toma at math.su.se]

References:

Herzog RI, Cummins TR, Waxman SG. (2001). Persistent TTX-resistant Na+ current affects resting potential and response to depolarization in simulated spinal sensory neurons. Journal of neurophysiology. 86 [PubMed]


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