"... Based on realistic modeling and experiments in rat hippocampal slices, we derived a simple arithmetic rule for spatial summation of concurrent excitatory glutamatergic inputs (E) and inhibitory GABAergic inputs (I). The somatic response can be well approximated as the sum of the excitatory postsynaptic potential (EPSP), the inhibitory postsynaptic potential (IPSP), and a nonlinear term proportional to their product (k*EPSP*IPSP), where the coefficient k reflects the strength of shunting effect. ..."
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I Na,t; I A; I K; I h
Receptors: GabaA; GabaB; AMPA; NMDA
Model Concept(s): Influence of Dendritic Geometry; Detailed Neuronal Models; Synaptic Integration
Simulation Environment: NEURON (web link to model)
References:
Hao J, Wang XD, Dan Y, Poo MM, Zhang XH. (2009). An arithmetic rule for spatial summation of excitatory and inhibitory inputs in pyramidal neurons. Proceedings of the National Academy of Sciences of the United States of America. 106 [PubMed]