A dopaminergic (DA) neuron model with a morphologicaly realistic dendritic architecture. The model captures several salient features of DA neurons under different pharmacological manipulations and exhibits depolarization block for sufficiently high current pulses applied to the soma.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Basal ganglia
Cell Type(s): Substantia nigra pars compacta DA cell
Currents: I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I K,Ca; Na/K pump
Model Concept(s): Activity Patterns; Temporal Pattern Generation; Oscillations
Simulation Environment: NEURON
Implementer(s): Huertas, Marco [huertas.marco at gmail.com]
References:
Kuznetsova AY, Huertas MA, Kuznetsov AS, Paladini CA, Canavier CC. (2010). Regulation of firing frequency in a computational model of a midbrain dopaminergic neuron. Journal of computational neuroscience. 28 [PubMed]