Excitation leads to rise in paranodal [K]e under the myelin. This causes structural changes in myelin structure and resistance. Current model aims to simulate this aspect. This is a space-clamped model of a double-cable nerve fibre.
Model Type: Extracellular
Cell Type(s): Myelinated neuron
Currents: I Na,p; I Na,t; I K; I K,leak; I_Ks; Na/K pump
Model Concept(s): Intermittent block
Simulation Environment: Lua
Implementer(s): Brazhe, Alexey [brazhe at gmail.com]
References:
Mosekilde E, Brazhe AR, Maksimov GV, Sosnovtseva O. (2010). Excitation block in a nerve fibre model owing to potassium-dependent changes in myelin resistance Journal of Interface Focus. 1(1)