" ... the main rhythms displayed by the hippocampus, the gamma (30–90 Hz) and theta (4–12 Hz) rhythms. We concentrate on modeling in vitro experiments, but with an eye toward possible in vivo implications. ... We use simpler biophysical models; all cells have a single compartment only, and the interneurons are restricted to two types: fast-spiking (FS) basket cells and oriens lacunosum-moleculare (O-LM) cells. ... , we aim not so much at reproducing dynamics in great detail, but at clarifying the essential mechanisms underlying the production of the rhythms and their interactions (Kopell, 2005). ..."
Model Type: Realistic Network; Neuron or other electrically excitable cell
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA3 pyramidal GLU cell; Hippocampus CA1 interneuron oriens alveus GABA cell; Neocortex fast spiking (FS) interneuron
Model Concept(s): Oscillations
Simulation Environment: MATLAB (web link to model)
References:
Tort AB, Rotstein HG, Dugladze T, Gloveli T, Kopell NJ. (2007). On the formation of gamma-coherent cell assemblies by oriens lacunosum-moleculare interneurons in the hippocampus. Proc Natl Acad Sci U S A 104 [PubMed]
Gloveli T, Dugladze T, Rotstein HG, Traub RD, Monyer H, Heinemann U, Whittington MA, Kopell NJ. (2005). Orthogonal arrangement of rhythm-generating microcircuits in the hippocampus. Proc Natl Acad Sci U S A 102 [PubMed]
Kopell N, Borgers C, Pervouchine D, Tort AB, Malerba P. (2010). Gamma and theta rhythms in biophysical models of hippocampal circuits Hippocampal Microcircuits: A Computational Modeller`s Resource Book. Ch. 15.