"Abnormalities in oscillations have been suggested to play a role in schizophrenia. We studied theta-modulated gamma oscillations in a computer model of hippocampal CA3 in vivo with and without simulated application of ketamine, an NMDA receptor antagonist and psychotomimetic. Networks of 1200 multi-compartment neurons (pyramidal, basket and oriens-lacunosum moleculare, OLM, cells) generated theta and gamma oscillations from intrinsic network dynamics: basket cells primarily generated gamma and amplified theta, while OLM cells strongly contributed to theta. ..."
Model Type: Realistic Network
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron
Currents: I L high threshold; I A; I K; I K,Ca
Receptors: GabaA; NMDA; Glutamate
Model Concept(s): Oscillations; Synchronization; Therapeutics; Pathophysiology; Schizophrenia; Information transfer; Brain Rhythms
Simulation Environment: NEURON; Python
Implementer(s): Lazarewicz, Maciej [mlazarew at gmu.edu]; Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org]
References:
Neymotin SA et al. (2011). Ketamine Disrupts Theta Modulation of Gamma in a Computer Model of Hippocampus The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]