Simulations of oscillations in piriform cortex (Wilson & Bower 1992)


"1. A large-scale computer model of the piriform cortex was constructed on the basis of the known anatomic and physiological organization of this region. 2. The oscillatory field potential and electroencephalographic (EEG) activity generated by the model was compared with actual physiological results. The model was able to produce patterns of activity similar to those recorded physiologically in response to both weak and strong electrical shocks to the afferent input. The model also generated activity patterns similar to EEGs recorded in behaving animals. 3. ..."

Model Type: Realistic Network

Region(s) or Organism(s): Olfactory cortex

Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; Neocortex fast spiking (FS) interneuron

Currents: I Chloride; I Na,t; I K

Receptors: GabaA; GabaB; AMPA

Model Concept(s): Oscillations; Extracellular Fields; Evoked LFP; Olfaction

Simulation Environment: GENESIS (web link to model)

References:

Wilson M, Bower JM. (1992). Cortical oscillations and temporal interactions in a computer simulation of piriform cortex. J Neurophysiol 67 [PubMed]

Bower JM, Beeman D. (2003). The book of GENESIS exploring realistic neural models with the GEneral NEural SImulation System (2nd ed)