NEURON mod files from the paper: Shah et al., 2011. In this study, using a combination of electrophysiology and computational modelling, we show that these channels selectively influence peri-somatic but not dendritic post-synaptic excitatory synaptic potential (EPSP) integration in CA1 pyramidal cells. This may be important for their relative contributions to physiological processes such as synaptic plasticity as well as patho-physiological conditions such as epilepsy.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I Na,t; I A; I K; I M; I h; I_AHP
Receptors: AMPA
Transmitters: Glutamate
Model Concept(s): Synaptic Integration
Simulation Environment: NEURON
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu]
References:
Shah MM, Migliore M, Brown DA. (2011). Differential effects of Kv7 (M-) channels on synaptic integration in distinct subcellular compartments of rat hippocampal pyramidal neurons. The Journal of physiology. 589 [PubMed]