...we built a multicompartmental model with a morphologically realistic three-dimensional reconstruction of a CA1 pyramidal neuron. The only active conductance we added to the model was the h conductance. ... We conclude that experimentally observed gradient in density of h channels could theoretically account for experimentally observed gradient in resonance properties (Narayanan and Johnston, 2007).
Model Type: Neuron or other electrically excitable cell; Dendrite
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I h
Model Concept(s): Ion Channel Kinetics; Active Dendrites; Detailed Neuronal Models
Simulation Environment: NEURON
Implementer(s): Narayanan, Rishikesh [rishi at iisc.ac.in]
References:
Narayanan R, Johnston D. (2007). Long-term potentiation in rat hippocampal neurons is accompanied by spatially widespread changes in intrinsic oscillatory dynamics and excitability. Neuron. 56 [PubMed]