A systems pharmacology model of the mammalian circadian clock including PF-670462 (CK1d/e inhibitor).
Model Type: Molecular Network
Cell Type(s): Suprachiasmatic nucleus (SCN) neuron
Model Concept(s): Therapeutics; Phase Response Curves; Circadian Rhythms
Simulation Environment: Mathematica
Implementer(s): Kim, Jae Kyoung [kimjack0 at kaist.ac.kr]
References:
Wood D et al. (2013). Modeling and validating chronic pharmacological manipulation of circadian rhythms CPT: Pharmacometrics & Systems Pharmacology. 2(7)