State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)


A Markov model of sodium channels was developed that includes drug binding to fast inactivated states. This was incorporated into a model of the dentate gyrus to investigate the effects of anti-epileptic drugs on neuron and network properties.

Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Channel/Receptor

Cell Type(s): Dentate gyrus granule GLU cell; Dentate gyrus mossy cell; Dentate gyrus basket cell; Dentate gyrus hilar cell

Currents: I Na,t; I A; I_AHP

Receptors: GabaA; AMPA

Transmitters: Gaba; Glutamate

Model Concept(s): Ion Channel Kinetics; Epilepsy; Calcium dynamics; Drug binding; Markov-type model

Simulation Environment: NEURON; MATLAB

Implementer(s): Thomas, Evan [evan at evan-thomas.net]

References:

Thomas EA, Petrou S. (2013). Network-specific mechanisms may explain the paradoxical effects of carbamazepine and phenytoin. Epilepsia 54 [PubMed]