Single compartment Dorsal Lateral Medium Spiny Neuron w/ NMDA and AMPA (Biddell and Johnson 2013)


A biophysical single compartment model of the dorsal lateral striatum medium spiny neuron is presented here. The model is an implementation then adaptation of a previously described model (Mahon et al. 2002). The model has been adapted to include NMDA and AMPA receptor models that have been fit to dorsal lateral striatal neurons. The receptor models allow for excitation by other neuron models.

Model Type: Neuron or other electrically excitable cell; Connectionist Network

Region(s) or Organism(s): Basal ganglia

Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum spiny neuron

Currents: I Na,p; I K; I K,leak; I A, slow; I_Ks; I Krp; I Na, leak

Receptors: AMPA; NMDA

Transmitters: Glutamate

Model Concept(s): Detailed Neuronal Models; Short-term Synaptic Plasticity; Parkinson's; Learning; Deep brain stimulation; Olfaction

Simulation Environment: NEURON

Implementer(s): Biddell, Kevin [kevin.biddell at gmail.com]

References:

Biddell K, Johnson J. (2013). A Biophysical Model of Cortical Glutamate Excitation of Medium Spiny Neurons in the Dorsal Lateral Striatum 56th IEEE Midwest Symposium on Circuits and Systems