Spreading depression model for FHM3 with Nav1.1 mutation (Dahlem et al. 2014)

Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura. A mutation causing FHM type 3 (FHM3) has been identified in SCN1A encoding the Nav1.1 Na+ channel. This genetic defect affects the inactivation gate. The code describes an extended Hodgkin-Huxley framework with dynamic ion concentrations in a wilde-type and mutant form.

Model Type: Neuron or other electrically excitable cell

Currents: I Na,t; I K; I K,leak; Na/K pump; I Cl, leak; I Na, leak

Genes: Nav1.1 SCN1A

Simulation Environment: XPPAUT

References:

Dahlem MA, Schumacher J, Hübel N. (2014). Linking a genetic defect in migraine to spreading depression in a computational model. PeerJ. 2 [PubMed]