" ... To study the mechanisms underlying SCS (Spinal cord stimulation), we constructed a biophysically-based network model of the dorsal horn circuit consisting of interconnected dorsal horn interneurons and a wide dynamic range (WDR) projection neuron and representations of both local and surround receptive field inhibition. We validated the network model by reproducing cellular and network responses relevant to pain processing including wind-up, A-fiber mediated inhibition, and surround receptive field inhibition. ..." See paper for more.
Model Type: Realistic Network
Cell Type(s): Wide dynamic range neuron
Receptors: GabaA; AMPA; NMDA; Glutamate; Glycine
Simulation Environment: NEURON
Implementer(s): Zhang, Tianhe [tz5@duke.edu]
References:
Zhang TC, Janik JJ, Grill WM. (2014). Modeling effects of spinal cord stimulation on wide-dynamic range dorsal horn neurons: influence of stimulation frequency and GABAergic inhibition. Journal of neurophysiology. 112 [PubMed]