Application to AMPA, NMDA, GABAA, and GABAB receptors is given in a book chapter. The reference paper synthesizes a comprehensive general description of synaptic transmission with Markov kinetic models. This framework is applicable to modeling ion channels, synaptic release, and all receptors. Please see the references for more details. A simple introduction to this method is given in a seperate paper Destexhe et al Neural Comput 6:14-18 , 1994). More information and papers at http://cns.iaf.cnrs-gif.fr/Main.html and through email: Destexhe@iaf.cnrs-gif.fr
Model Type: Synapse; Electrogenic pump
Receptors: Nicotinic; M1; M3; M4; M5; M2; mGluR1; mGluR2; mGluR3; mGluR4; mGluR5; mGluR6; mGluR7; mGluR8; Alpha; Alpha1; Alpha2; Beta; D1; D2; 5-HT1; 5-HT2; 5-HT4; H2; GabaA; GabaB; Muscarinic; AMPA; NMDA; mGluR; 5-HT3; Kainate; Monoamine Receptors; Glutamate; Gaba; Adrenergic; Serotonin; Histamine; Cholinergic Receptors; Amino Acid Receptors; Sensory Receptors; Olfactory Receptors; Opsins; Dopaminergic Receptor; Glycine; Gaseous Receptors; NO; Peptide Receptors; Dynorphin; H1; Ion Receptors; Zn2+; CO
Transmitters: Acetylcholine; Glycine; Dopamine; Zn2+; NO; CO; Dynorphin; Ephinephrine; Norephinephrine; Amino Acids; Gaba; Glutamate; Monoamines; Peptides; Ions; Gases; Histamine; Serotonin
Model Concept(s): Ion Channel Kinetics; Markov-type model
Simulation Environment: NEURON
Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr]; Mainen, Zach [Mainen at cshl.edu]
References:
Destexhe A, Mainen ZF, Sejnowski TJ. (1994). Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism. Journal of computational neuroscience. 1 [PubMed]
Sejnowski TJ, Destexhe A, Mainen Z. (1994). An efficient method for computing synaptic conductances based on a kinetic model of receptor binding Neural Comput. 6
Destexhe A, Sejnowski T, Mainen Z. (1995). Fast Kinetic Models for Simulating AMPA, NMDA, GABAA and GABAB Receptors The Neurobiology of Computation.