CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)


This model simulates the effects of dendritic sodium spikes initiated in distal apical dendrites on the voltage and the calcium dynamics revealed by calcium imaging. It shows that dendritic sodium spike promotes large and transient calcium influxes via NMDA receptor and L-type voltage-gated calcium channels, which contribute to the induction of LTP at distal synapses.

Model Type: Neuron or other electrically excitable cell; Synapse; Channel/Receptor; Dendrite

Region(s) or Organism(s): Hippocampus

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Currents: I L high threshold; I K; Ca pump; I Sodium

Receptors: AMPA; NMDA

Transmitters: Glutamate

Model Concept(s): Dendritic Action Potentials; Ion Channel Kinetics; Active Dendrites; Detailed Neuronal Models; Synaptic Plasticity; Long-term Synaptic Plasticity; Synaptic Integration; Calcium dynamics; Conductance distributions

Simulation Environment: NEURON

Implementer(s): Cembrowski, Mark S [cembrowskim at janelia.hhmi.org]; Hsu, Ching-Lung [hsuc at janelia.hhmi.org]

References:

Kim Y, Hsu CL, Cembrowski MS, Mensh BD, Spruston N. (2015). Dendritic sodium spikes are required for long-term potentiation at distal synapses on hippocampal pyramidal neurons. Elife 4 [PubMed]