Subiculum network model with dynamic chloride/potassium homeostasis (Buchin et al 2016)


This is the code implementing the single neuron and spiking neural network dynamics. The network has the dynamic ion concentrations of extracellular potassium and intracellular chloride. The code contains multiple parameter variations to study various mechanisms of the neural excitability in the context of chloride homeostasis.

Model Type: Synapse; Extracellular; Dendrite; Realistic Network; Glia

Region(s) or Organism(s): Hippocampus

Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hodgkin-Huxley neuron; Hippocampus CA1 PV+ fast-firing interneuron

Currents: KCC2; I Sodium; I Potassium; Na/K pump; I Calcium; I Chloride; I Cl, leak; I M; I Na, leak; I K,leak; I_HCO3; I Na,p

Receptors: NMDA; AMPA; GabaA

Transmitters: Ions; Gaba; Glutamate

Model Concept(s): Bursting; Epilepsy; Chloride regulation; Activity Patterns; Oscillations; Homeostasis; Potassium buffering; Brain Rhythms; Extracellular Fields

Simulation Environment: MATLAB; XPP

Implementer(s): Buchin, Anatoly [anat.buchin at gmail.com]

References:

Buchin A, Chizhov A, Huberfeld G, Miles R, Gutkin BS. (2016). Reduced Efficacy of the KCC2 Cotransporter Promotes Epileptic Oscillations in a Subiculum Network Model. J Neurosci 36 [PubMed]