We tested the reproducibility and comparability of four astrocyte models (Manninen, Havela, Linne, 2017). Model by De Pitta et al. (2009) was one of them. We implemented and ran the model by De Pitta et al. (2009) using Jupyter Notebook. Model code produces results of Figure 1 and Figures 3-5 in Manninen, Havela, Linne (2017).
Model Type: Glia
Region(s) or Organism(s): Generic
Cell Type(s): Astrocyte
Receptors: IP3
Transmitters: Glutamate
Model Concept(s): Calcium dynamics; Oscillations; Signaling pathways
Simulation Environment: Python
Implementer(s): Manninen, Tiina [tiina.h.manninen at gmail.com]
References:
De Pittà M, Goldberg M, Volman V, Berry H, Ben-Jacob E. (2009). Glutamate regulation of calcium and IP3 oscillating and pulsating dynamics in astrocytes. Journal of biological physics. 35 [PubMed]
Manninen T, Havela R, Linne M-L. (2017). Reproducibility and comparability of computational models for astrocyte calcium excitability Front. Neuroinform..
De Pittà M, Goldberg M, Volman V, Berry H, Ben-Jacob E. (2010). Erratum to: Glutamate regulation of calcium and IP(3) oscillating and pulsating dynamics in astrocytes. Journal of biological physics. 36 [PubMed]