Spatially uniform synaptic inhibition enhances spatial selectivity and temporal coding in CA1 place cells by suppressing broad out-of-field excitation.
Model Type: Neuron or other electrically excitable cell; Realistic Network
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Receptors: NMDA
Model Concept(s): Active Dendrites; Detailed Neuronal Models; Place cell/field; Synaptic Integration; Short-term Synaptic Plasticity; Spatial Navigation; Feature selectivity
Simulation Environment: NEURON; Python
Implementer(s): Milstein, Aaron D. [aaronmil at stanford.edu]
References:
Grienberger C, Milstein AD, Bittner KC, Romani S, Magee JC. (2017). Inhibitory suppression of heterogeneously tuned excitation enhances spatial coding in CA1 place cells. Nature neuroscience. 20 [PubMed]