Neural mass model of the sleeping thalamocortical system (Schellenberger Costa et al 2016)

This paper generates typical human EEG data of sleep stages N2/N3 as well as wakefulness and REM sleep.

Model Type: Neural mass

Region(s) or Organism(s): Thalamus; Neocortex

Cell Type(s): Neocortex L2/3 pyramidal GLU cell; Thalamus reticular nucleus GABA cell; Thalamus geniculate nucleus/lateral principal GLU cell; Neocortex U1 L6 pyramidal corticalthalamic GLU cell; Neocortex layer 2-3 interneuron

Currents: I Calcium; Na/K pump; I_K,Na

Receptors: AMPA; Gaba; NMDA

Model Concept(s): Calcium dynamics; Sleep; Activity Patterns; Oscillations; Bifurcation; Spindles; Audition

Simulation Environment: Network; C or C++ program (web link to model); MATLAB (web link to model)

Implementer(s): Schellenberger Costa, Michael [mschellenbergercosta at gmail.com]

References:

Weigenand A, Schellenberger Costa M, Ngo HV, Claussen JC, Martinetz T. (2014). Characterization of K-complexes and slow wave activity in a neural mass model. PLoS computational biology. 10 [PubMed]

Schellenberger Costa M et al. (2016). A Thalamocortical Neural Mass Model of the EEG during NREM Sleep and Its Response to Auditory Stimulation. PLoS computational biology. 12 [PubMed]