Nicotinic control of dopamine release in nucleus accumbens (Maex et al. 2014)


Minimal model of the VTA (ventral segmental area) representing two (GABA versus dopamine) neuron populations and two subtypes of nicotinic receptors (alpha4beta2 versus alpha7). The model is used to tell apart circuit from receptor mechanisms in the nicotinic control of dopamine release and its pharmacological manipulation.

Model Type: Neural mass; Channel/Receptor

Region(s) or Organism(s): Basal ganglia

Cell Type(s): Ventral tegmental area dopamine neuron

Receptors: Nicotinic

Transmitters: Acetylcholine; Dopamine; Gaba; Glutamate

Model Concept(s): Schizophrenia; Addiction; Volume transmission; Neuromodulation; Pathophysiology; Rate-coding model neurons; Simplified Models

Simulation Environment: XPP

Implementer(s): Maex, Reinoud [reinoud at bbf.uia.ac.be]

References:

Maex R, Grinevich VP, Grinevich V, Budygin E, Bencherif M, Gutkin B. (2014). Understanding the role a7 nicotinic receptors play in dopamine efflux in nucleus accumbens. ACS Chem Neurosci 5 [PubMed]